姓名：唐娟

学位：博士

导师情况：博士生导师

研究领域：细胞命运与心血管再生修复

E-mail: tangjuan@tongji.edu.cn

通讯地址：上海市杨浦区四平路1239号，3344体育官方入口，邮编200092

研究方向：

1. 解析心血管疾病中各类细胞命运变化及作用机制。

2. 探索心脏再生修复中的分子机制，为临床心血管疾病的治疗提供新靶点。

3. 开发遗传谱系示踪新技术，为心血管疾病研究提供新工具。

个人简介：

唐娟，3344体育官方入口“青年百人计划”A岗，长聘副教授，3344体育官方入口附属东方医院双聘研究员，博士生导师。国家自然基金优秀青年基金获得者（2023），上海市科委青年科技启明星（A类）获得者（2022）。入选中国科协“青年人才托举工程”（2018）、中国科学院“青年创新促进会会员”（2020）以及2022上海科技青年35人引领计划。2011年本科毕业于华中农业大学，2017年博士毕业于中国科学院上海生命科学研究院，随后在中国科学院分子细胞科学卓越创新中心从事博士后和副研究员工作，2021年7月加入3344体育官方入口。主要研究方向为细胞命运与心血管再生修复，致力于探索促进心血管再生和修复的有效策略。

目前在心血管再生修复领域以（共同）第一和通讯作者在Cell Stem Cell, Circulation, Circulation Research, Cell Research, Nature Communications等国际学术期刊上发表论文多篇。主持多个国家级和省部级科研项目，包括国家自然科学基金青年项目、面上项目以及上海市自然基金面上项目等，并以骨干身份参与2项国家重点研发计划。 

代表文章（*Co-first authors; #Corresponding authors）：

1. Gao Z*, Lu Z*, Meng J, Lin C, Zhang H^#, Tang J^#. Identification of mesenchymal-to-epithelial transition during heart regeneration through genetic lineage tracing. Stem Cell Research & Therapy. 2023; 14, 161. 

2. Huang X*, Yan L*, Meng J, Liu N, Zhu S, Jiang Z, Kou S, Feng T, Lin C, Zhou B, Tang J^#, Zhu P^#, Zhang H^#. Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model. Science China Life Sciences. 2023; 66; pages 51–66.

3. Lu Z, Jiang Z, Tang J^#, Lin C^#, Zhang H^#. Functions and origins of cardiac fat. The FEBS Journal. 2022.10.111/febs.16388.

4. Tang J*^#, Zhu H*, Tian X*, Wang H, Liu S, Liu K, Zhao H, He L, Huang X, Feng Z, Ding Z, Long B, Yan Y, Nicola S, Gong H, Luo Q^#, Zhou B^#. Extension of Endocardium-derived Vessels Generate Coronary Arteries in Neonates. Circulation Research. 2022;130;352-365.

5. Tang J*, Zhu H*, Wang H, Huang X, Zhou B^#. Sca1 marks a reserve endothelial progenitor population that preferentially expand after injury. Cell Discovery. 2021 Sep 28;7(1):88.

6. Tang J*, Wang H*, Huang X*, Li F*, Zhu H, Li Y, He L, Zhao H, Pu W, Liu, K, Zhang H, Bentzo J, Yu Y, Ji Y, Nie Y, Tian X, Zhang L^#, Gao D^#, Zhou B^#. Arterial Sca1⁺ vascular stem cells generate de novo smooth muscle for artery repair and regeneration. Cell Stem Cell. 2020;26: 81-96.

7. Tang J, Li Y, Huang X, He L, Zhang L, Wang H, Yu W, Tian X, Nie Y, Hu S, Lui KO, Zhou B^#. Fate mapping of sca1⁺ cardiac progenitor cells in the adult mouse heart. Circulation. 2018;138(25):2967–2969.

8. Tang J, Zhang H, He L, Huang X, Li Y, Pu W, Yu W, Zhang L, Cai D, Lui KO, Zhou B^#. Genetic fate mapping defines the vascular potential of endocardial cells in the adult heart. Circulation Research. 2018;122: 984-993.

9. Tang J, Shen Y, Chen G, Wan Q, Wang K, Zhang J, Qin J, Liu G, Zuo S, Tao B, Yu Y, Wang J, Lazarus M, Yu Y^#. Activation of e-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nature Communications. 2017; 8:14656.

10. Jin H*, Liu K*, Tang J*, Huang X, Wang H, Zhang Q, Zhu H, Li Y, Pu W, Zhao H, He L, Li Y, Zhang S, Zhang Z, Zhao Y, Qin Y, Pflanz S, Kasmi K, Zhang W, Liu Z, Ginhoux F, Ji Y, He B, Wang L, Zhou B^#. Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury. Nature Communications. 2021; 12, 2863 (2021).

11. Yan S*, Tang J*, Zhang Y, Wang Y, Zuo S, Shen Y, Zhang Q, Chen D, Yu Y, Wang K, Duan SZ, Yu Y^#. Prostaglandin e2 promotes hepatic bile acid synthesis by an e prostanoid receptor 3-mediated hepatocyte nuclear receptor 4alpha/cholesterol 7alpha-hydroxylase pathway in mice. Hepatology. 2017;65: 999-1014.

12. Zhang H*, Huang X*, Liu K*, Tang J*, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO, Zhou B^#. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Research. 2017;27: 1157-1177.

13. Chen D*, Tang J*, Wan Q, Zhang J, Wang K, Shen Y^#, Yu Y^#. E-prostanoid 3 receptor mediates sprouting angiogenesis through suppression of the protein kinase a/beta -catenin /notch pathway. Arteriosclerosis, Thrombosis, and Vascular biology. 2017;37: 856-866.