姓名：张梦欢

学位：博士

导师情况：博士生导师

研究领域：生物信息学

研究方向：多组学整合和疾病蛋白质组

E-mail：zhangmenghuan@tongji.edu.cn

通讯地址：上海市杨浦区四平路1239号，3344体育官方入口，邮编200092

个人简介：

2011年毕业于郑州大学生命科学学院，获学士学位。2016年毕业于上海交通大学生命科学技术学院，获博士学位。2016至2018年，在中国科学院上海营养与健康研究所从事博士后研究。2018年至2021年，在中国科学院分子细胞科学卓越创新中心先后任职助理研究员和副研究员。自2022年4月起被聘为3344体育官方入口副教授，博士生导师。

研究方向：通过开发计算和统计方法，将多组学数据转化为生物学和临床见解，以帮助阐明疾病的分子机制。近年来主要研究成果包括：1)多组学数据库的构建，尤其是蛋白质组；2)多组学分析方法在疾病中的应用。主持一项国家自然科学基金青年科学基金项目，被评为2019年度“中国科学院青年创新促进会”会员。在国内外学术期刊上以第一/通讯作者发表论文十余篇，包括Nucleic Acids Research, Journal of Hepatology，Cell Discovery等重要学术期刊。

代表论文：

1. Shilin Yuan^#, Guanghong Liao^#, Menghuan Zhang^#, Yuanfei Zhu^#, Kun Wang, Weidi Xiao, Caiwei Jia, Minhui Dong, Na Sun, Axel Walch, Ping Xu^*, Jiming Zhang^*, Qiang Deng^*, Ronggui Hu^*. Translatomic profiling reveals novel self-restricting virus-host interactions during HBV infection. Journal of Hepatology. 2021 Jul;75(1):74-85. doi: 10.1016/j.jhep.2021.02.009. Epub 2021 Feb 20.

2. Ming Li^#, Bingjie Hao^#, Menghuan Zhang^#, Russel J. Reiter, Shumeng Lin, Tiansheng Zheng, Xiangyun Chen, Yanbei Ren, Liduo Yue, Baigenzhin Abay, Guojie Chen, Xiao Xu, Yufeng Shi^*, Lihong Fan^*. Melatonin enhances radiofrequency-induced NK antitumor immunity, causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development. Signal Transduction and Targeted Therapy. 2021 Sep 1;6(1):330. doi: 10.1038/s41392-021-00745-7.

3. Shilin Yuan^#, Guanghong Liao^#, Menghuan Zhang^#, Yuanfei Zhu^#, Weidi Xiao^#, Kun Wang, Chuanyin Li, Caiwei Jia, Na Sun, Axel Walch, Daming Gao, Ping Xu^*, Qiang Deng^*, Jian Zhang^*, He Wang^*, Ronggui Hu^*. Multiomics interrogation into HBV (Hepatitis B virus)-host interaction reveals novel coding potential in human genome, and identifies canonical and non-canonical proteins as host restriction factors against HBV. Cell Discovery. (2021)7:105. doi.org/10.1038/s41421-021-00337-3.

4. Chuanyin Li^#, Tianting Han^#, Qing-Run Li^#, Menghuan Zhang^#, Rong Guo, Yun Yang, Wenli Lu, Zhengwei Li, Peng Chao, Ping Wu, Xiao Xu Tian, Qin Qin Wang, Yuexiang Wang, Vincent Zhou, Ziyan Han, Hecheng Li^*, Feng Wang^*, Ronggui Hu^*. MKRN3-mediated Ubiquitination of Poly(A)-binding Proteins Modulates the Stability and Translation of GNRH1 mRNA in Mammalian Puberty. Nucleic Acids Research. 2021 Apr 19;49(7):3796-3813. doi: 10.1093/nar/gkab155.

5. Jin Ren^#, Yun Yang^#, Chuanyin Li^#, Lu Xie, Ronggui Hu^*, Xiong Qin^*, Menghuan Zhang^*. A Novel Prognostic Model of Early-Stage Lung Adenocarcinoma Integrating Methylation and Immune Biomarkers. Frontiers in Genetics. 2021 Jan 21;11:634634. doi: 10.3389/fgene.2020.634634.

6. Ying Jiang^#, Aihua Sun^#, Yang Zhao^#, Wantao Ying^#, Huichuan Sun^#, Xinrong Yang^#, Baocai Xing^#, Wei Sun, Liangliang Ren, Bo Hu, Chaoying Li, Li Zhang, Guangrong Qin, Menghuan Zhang, Ning Chen, Manli Zhang, Yin Huang, Jinan Zhou, Yan Zhao, Mingwei Liu, Xiaodong Zhu, Yang Qiu, Yanjun Sun, Cheng Huang, Meng Yan, Mingchao Wang, Wei Liu, Fang Tian, Huali Xu, Jian Zhou, Zhenyu Wu, Tieliu Shi, Weimin Zhu, Jun Qin, Lu Xie, Jia Fan^*, Xiaohong Qian^*, Fuchu He^* & Chinese Human Proteome Project (CNHPP) Consortium. Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma. Nature. 567, 257–261 (2019).

7. Menghuan Zhang^#, Hui Cui^#, Lanming Chen, Ying Yu^*, Michael O Glocker^*, Lu Xie^*. PhoPepMass: A database and search tool assisting human phosphorylation peptide identification from mass spectrometry data. Journal of Genetics and Genomics. 2018 July 9. doi.org/10.1016/j.jgg.2018.07.005.

8. Qingmin Yang^#, Yuqi Zhang^#, Hui Cui, Lanming Chen, Yong Zhao, Yong Lin^*, Menghuan Zhang^*, Lu Xie^*. dbDEPC 3.0: the database of differentially expressed proteins in human cancer with multi-level annotation and drug indication. Database (Oxford). 2018 Jan 1;2018. doi: 10.1093/database/bay015.

9. Menghuan Zhang, Bo Wang, Jia Xu, Xiaojing Wang, Lu Xie, Bing Zhang^*, Yixue Li^*, Jing Li^*. CanProVar 2.0: An Updated Database of Human Cancer Proteome Variation. Journal of Proteome Research. 2017 Feb 3;16(2):421-432. doi: 10.1021/acs. jproteome.6b00505.

10. Menghuan Zhang, Hong Li, Ying He, Jing Li, Li Xia, Lishun Wang, Peng Cui, Bo Sun, Jing Li^*, Yixue Li^*, Lu Xie^*. Construction and deciphering of human phosphorylation mediated signaling transduction network. Journal of Proteome Research. 2015 Jul 2;14(7):2745-57. doi: 10.1021/acs.jproteome.5b00249.

11. Ying He^#, Menghuan Zhang^#, Yuanhu Ju, Zhonghao Yu, Daqing Lv, Han Sun, Weilan Yuan, Fei He, Jianshe Zhang, Hong Li, Jing Li, Rui Wang-Sattler, Yixue Li^*, Guoqing Zhang^*, Lu Xie^*. dbDEPC 2.0: updated database of differentially expressed proteins in human cancers. Nucleic Acids Research. 2012 Jan;40(Database issue): D964-71. doi: 10.1093/nar/gkr936.