姓        名：康岚

学        位：博士

导师情况：博士生导师

研究领域：干细胞生物学，发育生物学

研究方向：

      1、非编码RNA在胚胎发育中的功能及调控机制。

      2、多能干细胞向生殖细胞定向分化的机制及应用。     

      3、体细胞重编程的分子机制。

E-mail: kanglan@tongji.edu.cn
联系电话：021-65987363
通讯地址：上海市四平路1239号3344体育官方入口

实验室网址：/gaolab/

个人简历：

研究方向简介：

康岚博士主要研究方向是胚胎发育中的表观调控以及多能性调控机制和应用。2009年首次证明了iPS细胞的完全多能性，在国内外引起广泛关注，被美国时代杂志评为2009年世界十大医学突破之一。获得多项国家及省部级科研基金支持，入选国家自然科学基金委优秀青年项目，以第一作者或通讯作者在本领域知名期刊Nature Communications，Cell Research，Cell Stem Cell等期刊上发表多篇论文，累计引用600余次。

      
 代表性论文：

1. Zhu J, Chen K, Sun Y, Ye W, Liu J, Zhang D, Su N, Kou X, Zhao Y, Wang H, Gao S#, Kang L#. LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei. Nature Communications 14(1):957 (2023). (Correspondence author)

2.  Wu L, He S, Ye W, Shen J, Zhao K, Zhang Y, Zhang R, Wei J, Cao S, Chen K, Le R, Xi C, Kou X, Zhao Y, Wang H, Kang L#, Gao S#. Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress. Cell Proliferation 54(11):e13133 (2021). (Co-correspondence author)

3.  He J, Ye W, Kou N, Chen K, Cui B, Zhang X, Hu S, Liu T#, Kang L#, Li X#. MicroRNA-29b-3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway. Journal of Cellular and Molecular Medicine 24(1):841-849 (2020). (Co-correspondence author)

4.  Kang L*, Chen J*, Gao S. Historical review of reprogramming and pluripotent stem cell research in China.Yi Chuan 20;40(10):825-840 (2018). (First author)

5. Wu L, Wu Y, Peng B, Hou Z, Dong Y, Chen K, Guo M, Li H, Chen X, Kou X, Zhao Y, Bi Y, Wang Y, Wang H, Le R, Kang L#, Gao S (2017)  Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation.Stem Cell Reports 9(5):1692-1705 (Co-correspondence author)

6. Li X, Ma C, Zhang L, Li N, Zhang X, He J, He R, Shao M, Wang J, Kang L#, Han C (2017)LncRNAAC132217.4, a KLF8-regulated long non-coding RNA, facilitates oral squamous cell carcinoma metastasis by upregulating IGF2 expression.Cancer Letter 407:45-56. (Co-correspondence author)

7. Qin S, Yang D, Chen K, Li H, Zhang L, Li Y, Le R, Li X, Gao S and Kang L (2017)Pkm2 can enhance pluripotency in ESCs and promote somatic cell reprogramming to iPSCs.Oncotarget 8:84276-84284. (Co-correspondence author)

8. Feng X, Xu X, Xiao X, Zou K, Yu W, Wu J, Tang R, Gao Y, Hao J, Zhao X, Liao Y, Chen Y, Huang W, Guo W, Kang L#, Deng W (2017)NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer.Cell Death & Disease 8(5):e2783. (Co-correspondence author)

9. Wang M, Zhang Y, Wang T, Zhang J, Zhou Z, Sun Y, Wang S, Shi Y, Luan X, Zhang Y, Wang Y, Wang Y, Zou Z, Kang L#, Liu H (2015)The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status.Cell Physiol Biochem 43(5):1755-1766. (Co-correspondence author)

10. Hao J, Xu H, Luo M, Yu W, Chen M, Liao Y, Zhang C, Zhao X, Jiang W, Hou S, Feng X, Zou K, Chen Y, Huang W, Guo W, Kang L#, Deng W (2017)The tumor-promoting role of TRIP4 in melanoma progression and its involvement in response to BRAF-targeted therapy.J Invest Dermatol 138(1):159-170 (Co-correspondence author)

11. Kang L, Gao S. Generation of Viable Mice from Induced Pluripotent Stem Cells (iPSCs) Through Tetraploid Complementation. Methods in Molecular Biology. 1330:125-32 (2015). (First author)

12. Kang L#, Wu J, Tao Y, Li H,Liu X,Gao S, Wang Q (2015)Cell Type-Specific Expression Profile and Signaling Requirements in Early Hematopoietic Reprogramming.Stem Cells and Development 24(12):1483-92. (Co-correspondence author)
    

13. Kang L, Gao S (2012)Pluripotency of induced pluripotent stem cells.J Anim Sci Biotechnol 2012 Feb 28;3(1):5

14. Kang L, Wu T, Tao Y, Yuan Y, He J, Zhang Y, Luo T, Kou Z, Gao S (2011)Viable mice produced from three-factor induced pluripotent stem (iPS) cells through tetraploid complementation.Cell Research 21(3):546-9.

15. Kang L, Kou Z, Zhang Y, Gao S (2010)Induced pluripotent stem cells (iPSCs)--a new era of reprogramming.Journal of Genetics and Genomics 7(7):415-21.

16. Kou Z*, Kang L*, Yuan Y, Tao Y, Zhang Y, Wu T, He J, Wang J, Liu Z, Gao S (2010)Mice cloned from induced pluripotent stem cells (iPSCs).Biology of Reproduction 83(2):238-43. (Co-first author)

17. Kang L, Wang J, Zhang Y, Kou Z, Gao S (2009)iPS cells can support full term development of tetraploid blastocyst-complemented embryos.Cell Stem Cell 5(2):135-138.