姓         名：毛志勇 

行政职务：3344体育官方入口附属第一妇婴保健院转化医学研究中心主任

学         位：博士

导师情况：博士生导师

研究领域：衰老、干细胞及妇科肿瘤相关DNA修复

联系电话：021-65978166

通讯地址：上海市四平路1239号，3344体育官方入口（200092）

个人简介:

毛志勇，教授，博士生导师，国家杰青、国家优青、海外高层次青年人才。2002、2004年先后毕业于南京大学生命科学学院，获学士和硕士学位；2010年毕业于美国罗彻斯特大学，获博士学位，主要从事DNA双链断裂修复的分子生物学机制的研究。2010年-2012年于罗彻斯特大学生物系从事博士后研究，主要研究方向是衰老以及肿瘤与DNA修复之间的关系。2012年9月于3344体育官方入口建立课题组开展衰老、干细胞及妇科肿瘤相关基因组稳定性的机制研究。

毛志勇教授现已在Nature、Nature Cancer、PNAS、Nature Communications、Nucleic Acids Res.、Cell Death Differ.、eLife、Cell Reports、Oncogene、Aging Cell等重要学术期刊发表通讯（含共同）作者论文20余篇，在Science、PNAS等学术期刊发表第一（含共同）作者论文7篇。

毛志勇教授于2013年担任科技部“973”计划青年项目首席科学家，2013年获上海市“浦江人才”项目资助，2016年获国家自然科学基金委优秀青年科学基金项目资助，2019年获上海市“优秀学术带头人”项目和“曙光计划”资助，2022年获国家杰出青年科学基金项目资助。毛志勇教授2021年获上海市医学科技奖三等奖（第一完成人），2019年获上海市银蛇奖提名。

毛志勇课题组具有完整的科研梯队，现有教授1名、副教授1名、助理教授及助理研究员4名、博士后2名、博士生12名、硕士生5名、多名本科生。已毕业博士9名，硕士9名。课题组先后有10人次获得研究生国家奖学金及其他校级奖学金，毕业同学均在重要高校、科研院所、企事业单位继续从事教学和科研相关工作。

代表性文章：

^2024年

^{1. Zhang H, Jiang L, Du X, Qian Z, Wu G*, Jiang Y*, Mao Z*. cGAS-Ku80 complex regulates the choice of two nonhomologous end joining pathways. Cell Death Differ. 2024. * Corresponding authors.}

2. Geng A, Sun J, Tang H, Yu Y, Wang X, Zhang J, Wang X, Sun X, Zhou X, Gao N, Tan R, Xu Z, Jiang Y, Mao Z*. SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner. Nucleic Acids Res. 2024 Mar 30:gkae190.*Corresponding authors.

^{3. Chen Y*, Xu X, Chen Z, Chen L, Jiang Y*, Mao Z*. Circadian factors CLOCK and BMAL1 promote nonhomologous  end joining and antagonize cellular senescence. Life Medicine. 2024 Feb 4:lnae006. * Corresponding authors.}

^2023年

1. Zhen Z, Chen Y, Wang H, Tang H, Zhang H, Liu H, Jiang Y, Mao Z*. Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation. Nature Communications. 2023 Dec 12;14(1):8217. * Corresponding authors.

2. Chen Y, Zhen Z, Chen L, Wang H, Wang X, Sun X, Song Z, Wang H, Lin Y, Zhang W, Wu G, Jiang Y*, Mao Z*. Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription. Embo Rep. 2023 Dec 6;24(12):e56984.* Corresponding authors.

3. Chen Y, Huang S, Cui Z, Sun X, Tang Y, Zhang H, Chen Z, Jiang R, Zhang W, Li X, Chen J, Liu B, Jiang Y, Wei K*, Mao Z*. Impaired end joining induces cardiac atrophy in a Hutchinson–Gilford progeria mouse model. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2309200120. * Corresponding authors.

4. Sun X, Tang H, Chen Y, Chen Z, Hu Z, Cui Z, Tao Y, Yuan J, Fu Y, Zhuang Z, He Q, Li Q, Xu X, Wan X, Jiang Y*, Mao Z*. Loss of ER/PR/HER2 promotes USP15-dependent stabilization of PARP1 in triple-negative breast cancer. Nature Cancer. 2023 May;4(5):716-733. * Corresponding authors.

5. Zhang W, Wang M, Song Z, Fu Q, Chen J, Zhang W, Gao S, Sun X, Yang G, Zhang Q, Yang J, Tang H, Wang H, Kou X, Wang H, Mao Z*, Xu X*, Gao S*, Jiang Y*. Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer. Nature Communications. 2023 Apr 3;14(1):1838. * Corresponding authors.

2022年

^{1. Chen Y, Cui Z, Chen Z, Jiang Y}*^{, Mao Z}*^{. IDDoR: A novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways. Protein & Cell. 2022 Oct 14. pwac001, https://doi.org/10.1093/procel/pwac001. * Corresponding authors.}

^{2. Zhao K, Sun X, Zheng C, Wang M, Xu Z, Wang M, Chen J, Guo M, Le R, Wu L, Wang Y, Kou X, Zhao Y, Yin J, Wang H, Mao Z}*, ^{Gao S}*.. ^{Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs. Science Bulletin. 2022 Apr 3. * Corresponding authors.}

^2021年

^{Zhang W, Yang J, Chen Y, Xue R, Mao Z}*^{, Lu W*, Jiang Y*. Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells. Aging Cell. 2021 Feb;20(2):e13307. doi: 10.1111/acel.13307. * Corresponding authors.}

^2020年

^{1. Wang C, Tang H, Geng A, Dai B, Zhang H, Sun X, Chen Y, Qiao Z, Zhu H, Yang J, Chen J, He Q, Qin N, Xie J, Tan R, Wan X, Gao S, Jiang Y*, Sun FL*, Mao Z*. Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PKcs inhibitors.Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26356-26365. * Corresponding authors.}

^{2. Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z*. Fight to the bitter end: DNA repair and aging. Ageing Research Reviews.2020 Sep 22;64:101154. * Corresponding author.}

^{3. Geng A, Tang H, Huang J, Qian Z, Qin N, Yao Y, Xu Z, Chen H, Lan L, Xie H, Zhang J, Jiang Y, Mao Z*. The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2. Nucleic Acids Res.2020 Sep 18;48(16):9181-9194. * Corresponding author}

^{4. Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J*, Gao S*, Mao Z*. The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells. Aging Cell. 2020. doi: 10.1111/acel.13185. * Corresponding authors.}

^{5. Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J*, Gao S*, Mao Z*. A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing. eLife. 2020. Jul 9;9:e56008. doi: 10.7554/eLife.56008. * Corresponding authors.}

^{6. Zhang H, Cai B, Geng A, Tang H, Zhang W, Li S, Jiang Y, Tan R*, Wan X*, Mao Z*. Base excision repair but not DNA double strand break repair is impaired in aged human adipose-derived stem cells (ADSCs). Aging Cell.2020 Feb;19(2):e13062. doi: 10.1111/acel.13062. * Corresponding authors.}

^2019年

^{1. Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, SuT, ShiJ, Jiang C, Tian X, SeluanovA, HuangJ, WanX, Jiang Y*, Gorbunova V*, Mao Z*. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res.2019 Jul 10. pii: gkz592. doi: 10.1093/nar/gkz592. * Corresponding authors.} 

^{2. Tang H, Geng A, Zhang T, Wang C, Jiang Y, Mao Z*.Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion. Protein & Cell. 2019 May;10(5):370-375. doi: 10.1007/s13238-018-0591-y. * Corresponding author.} 

^2018年

^{1. Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SH, Chen C, Mao Z*, Ge B*. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature. 2018 Nov;563(7729):131-136. doi: 10.1038/s41586-018-0629-6. Epub 2018 Oct 24. * Corresponding authors.} 

^{2. Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y*, Mao Z*.Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy. Cell Death & Disease. 2018 Mar 16;9(4):420. doi: 10.1038/s41419-018-0453-9. * Corresponding authors.}

^2017年

^{1. Yu Y, Tang R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y*, Li Lan*, Mao Z*. POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions. Aging (Albany NY). 2017 Dec 8;9(12):2529-2543. * Corresponding authors.}

^{2. Zhang F, Tang H, Jiang Y*, Mao Z*. The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression. Oncogene. 2017 Sep 7;36(36):5168-5176. doi: 10.1038/onc.2017.127. * Corresponding authors.}

^{3. Chen W, Liu N, Zhang H-X, Zhang H-P, Qiao J, Jia W, Zhu S, Mao Z*, Kang J*. Sirt6 promotes DNA end joining in iPS cells derived from old mice. Cell Reports.2017 March 21: 18: 2880–2892. * Corresponding authors.}

^2016年

^{1. Li Z, Zhang W, Chen Y, Guo W, Zhang J, Tang H, Xu Z, Zhang H, Tao Y, Wang F, Jiang Y, Sun FL, Mao Z*. Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans.Cell Death Differ. 2016 Nov 1;23(11):1765-1777. doi: 10.1038/cdd.2016.65.Corresponding author.}

^2015年

^{1. Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z*, Sun FL*. RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1. Mol Cell Biol.2015 Jan 15;35(2):406-16. * Corresponding authors.}

^{2. Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z*.SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle.2015;14(2):269-76. doi: 10.4161/15384101.2014.980641. * Corresponding author.}

^{第一（含共同第一）作者论文}

^{1.Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A.Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11800-5.}

^{2. Mao Z, Ke Z, Gorbunova V, Seluanov A. Replicatively senescent cells are arrested in G1 and G2 phases.Aging (Albany NY). Jun;4(6):431-5.}

^{3. Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V. SIRT6 promotes DNA repair under stress by activating PARP1.Science.17 June 2011: 1443-1446.}

^{4. Mao Z#, Jiang Y#, Liu X, Seluanov A, Gorbunova V. DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia.2009 Jul; 11(7):683-691. # These authors contributed equally to this work.}

^{5. Mao Z#, Bozzella M#, Seluanov A, Gorbunova V. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle. 2008 Sep 15; 7:18, 1-5. # These authors contributed equally to this work.}

^{6. Mao Z, Bozzella M, Seluanov A, Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst). 2008 Oct 1;7(10):1765-71.}

^{7. Mao Z, Seluanov A, Jiang Y, Gorbunova V. TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13068-73.}