学术报告

(3月9日) Identifying Disease Genes from Biomolecular Networks

发布时间:2017-02-28  

 

报告人: Prof. Fangxiang Wu (吴方向),Department of Computer Science ,University of Saskatchewan,Canada

计算机学院, 中南大学, 中国

主持人:刘琦 教授

时间:2017年3月9日(周四)上午10:00- 11:20

地点:医学楼1102室

 

报告简介:

      It is well known that a complex disease stems from the malfunctions of some biomelcular networks which control the pathogenesis of the complex disease. Disease genes can be viewed as special nodes in biomolecular networks and are not randomly distributed (located) from existing evidences. The identification of disease genes is critical towards the understanding of complex diseases. We formulated identifying disease genes from a biomolecular network as finding the most possible configuration of the network. Borrowing from statistical mechanics, we employed the Boltzmann distribution to compute the probability of configurations of a network while adopting the Ising model to define the network energy. In this talk, I will present some of our recent results for identifying disease genes from biomolecular networks based on our proposed statistical mechanics-based methods.

 

报告人简介:

    吴方向,加拿大萨省大学计算机学院生物医学工程系教授,中南大学计算机学院教授,博士生导师,IEEE senior member。吴方向教授是国际著名的非线性控制理论和生物信息学专家。早年毕业于大连理工大学(本科,应用数学方向),西北工业大学(硕士,控制理论方向),加拿大萨省大学(博士,系统生物学方向),加拿大拉瓦尔大学(博士后),具有多学科交叉的研究背景。吴方向教授将控制的非线性理论应用于生物信息学和生物复杂网络,脑图像和脑网络的动态分析中,在该领域做出了一系列研究成果,在相关的计算生物学权威期刊及IEEE、ACM相关transaction等发表论文260余篇。

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