报 告 人：Wang Zhiyong

主 持 人：李维达教授

时    间：7月18日 星期一 9：30——10:30

地    点：医学大楼1101室

Research Focus

      The goal of the proposed research is to develop standardized and easy to use procedure to isolate brown adipose tissue (BAT) preadipocytes for transplantation to combat obesity and diabetes. I have the expertise, leadership and motivation in both academic and industrial settings necessary to successfully carry out the proposed work as the Principal Investigator. I also have studied energy balance and metabolism in vivo with genetically modified mice. As PI on several California- and NIH-funded grants, I have established a variety of in vivo mouse models and cell-based assay systems to accomplish the proposed goals for improvements of human diseases. In addition, I successfully administered the projects (e.g. staffing, research protections, budget), collaborated with other researchers, and produced several peer-reviewed publications from my past projects.In addition, I have been working on BAT, stem cell biology and in vivo obesity models during the past 15 years.

Employment and Education

• 1997.1-2001.7 Postdoctoral Fellow, University of California, San Diego
• 2001.8-2009.11 Postdoctoral Fellow, Salk Institute for Biological Studies, San Diego, CA
• 2009.12-2013.4 Senior Scientist, Fate Therapeutics, San Diego, CA
• 2013.11-present Co-Founder and CEO, ADS Biosystems Inc., San Diego, CA

Selected Publications

•  Wang Z, Shah OJ, Hunter T (2012). The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models. PLoS One.2012;7(7):e36961.Epub 2012 Jul 31.
• Wang Z, Qi C, Krones A, Woodring P, Zhu X, Reddy JK, Evans RM, Rosenfeld MG, and Hunter T. (2006). In vivo roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metabolism 3:111-122.
• Shah OJ, Wang Z, Hunter T. (2004). Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Current Biology 14:1650
• Wang Z, Rose DW, Hermanson O, Liu F, Herman T, Wu W, Szeto D, Gleiberman A, Krones A, Pratt K, Rosenfeld R, Glass CK, Rosenfeld MG. (2000). Regulation of somatic growth by the p160 coactivator p/CIP. Proc Natl Acad Sci U S A. 97:13549