报 告 人：林思劼，博士，教授
                同济环境科学与工程学院
                

主 持 人：张超 教授

时 间：2016 年4 月18 日周一上午10:00-11:00

地 点：医学大楼1102 室

Research Background
      The sustainable development of nanotechnology requires thorough understanding of the potential risk of engineering nanomaterials and nanostructures to the biological systems. Zebrafish, as a versatile animal model, has increasingly been used for studying the environmental implications of nanotechnology. This talk aims to stimulate interest for research collaborations by covering: (1) the establishment of a high throughput platform for toxicity screening using zebrafish embryos; (2) the mechanistic understanding of the hatching interference exerted by transition metal oxide nanomaterials; and (3) the aspect ratio-dependent toxicity of CeO2 nanomaterials to zebrafish developing larvae.

Employment and Education

2015-2016 Project Scientist, University of California, Los Angeles, USA

2010-2015 Postdoctoral researcher, University of California, Los Angeles, USA

2007-2010 Ph.D., Clemson University, South Carolina, USA

2005-2007 M.S., Clemson University, South Carolina, USA

2001-2005 B.S., Materials Science and Engineering, Tongji University, China

Selected Publications
[1] Lin S., Taylor A. A., Ji Z., Chang C. H., Walker T., Walker S., and Nel A. E. Understanding the Transformation, Speciation, and Hazard Potential of Copper Particles in a Model Septic Tank System Using Zebrafish to Monitor the Effluent. ACS Nano, 2015, 9, 2038-2048.
[2] Lin S., Wang, X., Ji Z., Chang C. H., Dong, Y., Meng, H., Liao, Y. P., Wang, M., Song, T. B., Kohan, S., Xia, T., Zink, J. I., Lin, S. and Nel A. E. Aspect Ratio Plays a Role in the Hazard Potential of CeO2 Nanoparticles in Mouse Lung and Zebrafish Gastrointestinal Tract. ACS Nano 2014, 8, 4450-4464.
[3] Lin S., Zhao Y., Ji Z., Ear J., Chang C.H., Zhang H., Low-Kam C., Yamada K., Meng H., Wang X., Liu R., Pokhrel S., Mädler L., Damoiseaux R., Xia T., Godwin H.A., Lin S. and Nel A.E. Zebrafish High-Throughput Screening to Study the Impact of Dissolvable Metal Oxide Nanoparticles on the Hatching Enzyme, ZHE1. Small 2013, 9, 1776-1785.
[4] Lin S., Zhao Y., Nel A.E. and Lin S. Zebrafish: An In Vivo Model for Nano EHS Studies. Small 2013, 9, 1608-1618.
[5] Lin S., Zhao Y., Xia T., Huan M., Ji Z., Liu R., George S., Xiong S., Wang X., Zhang H., Pokhrel S., Mädler L., Damoiseaux R., Lin S. and Nel A.E. High Content Screening in Zebrafish Speeds up Hazard Ranking of Transition Metal Oxide Nanoparticles. ACS Nano 2011, 5, 7284-7295.
[6] Muller, E. B., Lin, S., and Nisbet R. M. Quantitative Adverse Outcome Pathway Analysis of Hatching in Zebrafish with CuO Nanoparticles. Environ. Sci. Technol. 2015, 49, 11817-11824.
[7] Nel A.E., Xia T., Meng H., Wang X., Lin S., Ji Z. and Zhang H. Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High Throughput Screening. Accounts Chem. Res. 2013, 46, 607-621.