报告人：魏珂 博士

主持人：高绍荣教授

时间：2016年3月18日 上午10:00

地点：医学楼1102室

Research Focus

• My research is focused on understanding cardiovascular development and regeneration. Using in vivo mouse development and disease models and in vitroHigh-Content-Screening platforms based on cardiomyocytes derived from stem cells, I am trying to identify and study novel molecules and pathways regulating cardiovascular development and diseases, focusing on regeneration of functional cells in the heart, aiming to develop novel therapeutic tools to treat heart diseases. Particularly, I identified FSTL1 as an epicardial secreted protein promoting cardiomyocyte proliferation in vitro, and reconstituting FSTL1 through engineered epicardium can regenerate the adult mammalian heart.
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Employment and Education

• 2008.06-Present         Postdoctoral Associate, Sanford Burnham Prebys Medical Discovery Institute
• 2002.09-2008.06        Ph.D. in Molecular Cellular and Integrative Physiology, UCLA
• 1998.09-2002.06        B.S. in Biological Sciences and Biotechnology, Tsinghua University, China
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Selected Publications

• 1. Ke Weiet al. Epicardial FSTL1 Reconstitution Regenerates the Adult Mammalian HeartNature 525: 479-485 (2015)
• 2. Ke Weiet al.Developmental origin of age-related coronary artery disease Cardiovascular Research 107 (2): 287-294 (2015)
• 3.  Ke Weiet al.Neural Crest Cell Deficiency of c-myc Causes Skull and Hearing DefectsGenesis 45(6): 382-390 (2007)
• 4. Ke Weiet al.Generation of mice deficient for Lbx2, a gene expressed in the urogenital system, nervous system and Pax3 dependent tissues Genesis 45(6): 361-368 (2007)
• 5. Ke Weiet al. Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression Developmental Dynamics 236(2): 416-425 (2007)