报告人：Yanwen Jiang, PhD, Instructor

        Weill Cornell Medical College, New York

主持人：邱安东教授

时  间：2016年1月13日上午10:30-11:30

地  点：医学大楼1102室

Education

2007:PhD, Cancer Biology, University of Chicago

2000: MS, Biological Sciences, Eastern Illinois University

1997: BS, Biochemistry, East China University of Science and Technology

Research

2014-present: Instructor in Physiology and Biophysics,Weill Cornell Medical College

2009-2014: Postdoc, Elemento and Melnick Laboratories, Weill Cornell Medical College

2007-2009: Postdoc, Le Beau Laboratory, University of Chicago

2000-2007: Research Assistant, University of Chicago

1998-2000: Research Assistant, Britto Laboratory, Eastern Illinois University

      Dr. Jiang is currently leading a team of postdocs and technicians to investigate: (1) the roles of epigenetic modifiers (CREBBP, EP300, KMT2D, etc.) in normal mature B-cell development, humoral response, and malignant transformation into non-Hodgkin’s lymphoma using genetic engineered animals and genomics approaches including RNA-seq, ChIP-seq, ATAC-seq, Drop-seq, and eRRBS; (2) transcription regulation via enhancers in normal mature B cells and aberrations of enhancer usage in malignant B cells; (3) ncRNAs (lncRNAs and eRNAs) functions in physiological germinal center reaction, and their involvement in malignant transformation; (4) therapeutics targeting aberrant epigenetic enhancer regulation and identifying PD markers in non-Hodgkin's lymphoma.

      Dr. Jiang has published 26 research articles in Science, Nature Medicine, Cancer Cell, Nature Communications, Genome Biology, Blood, Cancer Discovery, etc.

Selected recent publications

• Ortega-Molina, A., Boss, IW.,Canela, A., Pan, H., Jiang, Y., et al. The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Nature Medicine, 21, 1199-1208, 2015.
• Pan, H., Jiang, Y(co-1^st author),et al. Epigenomic evolution in diffuse large B-cell lymphomas. Nature Communications, 6:6921, 2015.
• Jiang, Y, et al. Deep-sequencing reveals clonal evolution patterns and mutation events associated with relapse in B cell lymphomas. Genome Biology,15: 432, 2014.
• Jiang, Y, Hatzi, K, and Shaknovich, R. Mechanisms of epigenetic deregulation in lymphoid neoplasms. Blood,121:4271-4279, 2013.