研究方向：发布

    1）干细胞全能性形成、基因组稳定性及向神经和心肌定向分化的表观遗传机制（非编码RNA、组蛋白修饰和DNA甲基化等）
    2）肿瘤形成的信号转导、免疫和表观遗传机制

       实验室多位具有博士学位的工作人员，共同从学术思想和技术细节等方面指导学生，2022年干细胞与表观遗传实验室荣获3344体育官方入口第二届“卓越”研究生导学团队标兵称号。

实验室工作人员：

汪贵英   教授，博导，复旦大学博士

郭旭东   长聘副教授/特聘研究员，博导，3344体育官方入口博士

贾文文   副教授，博导，西北农林科技大学与美国宾夕法尼亚大学联合 培养博士

陈 文    副教授，硕导 ，中科院北京动物所博士

李 昂    副研究员，硕导，3344体育官方入口博士

冷 晔    副教授，3344体育官方入口博士

朱颂成   副教授，中科院上海生科院博士，美国科罗拉多大学波尔得分校博士后

武玉康   工程师，3344体育官方入口博士

高莹莹   工程师，3344体育官方入口博士

实验室自建立以来，年轻教师和学生共同成长，在Cell Stem Cell、PNAS、Cell Res、Nucleic Acids Res等国际杂志发表论文百余篇。

实验室在读学生：

博士后：李建国

研究生：朱蔚，常书娟，王铻鋋，郭雪聪，连一霖，谈爱玲，徐瑞婷，黎璇，赵鑫，周倩，苏海煜，黄颖慧，高贵宇，王宇航，李梦思，蔡茜茜，徐欣蕊，贾怡莎，孙正昊，卫兵，游时霖，毛智远。

代表性文章（#为通讯作者）

1. Sun Q, Ma L, Qiao J, Wang X, Li J, Wang Y, Tan A, Ye Z, Wu Y, Xi J#, Kang J#. MiR-181a-5p promotes neural stem cell proliferation and enhances the learning and memory of aged mice. Aging Cell. 2023; 22(4):e13794.

2. Xi J, Xu Y, Guo Z, Li J, Wu Y, Sun Q, Wang Y, Chen M, Zhu S, Bian S, Kang J#. LncRNA SOX1-OT V1 acts as a decoy of HDAC10 to promote SOX1-dependent hESC neuronal differentiation. EMBO Rep. 2022; 23(2):e53015.

3.Xu Y, Xi J, Wang G, Guo Z, Sun Q, Lu C, Ma L, Wu Y, Jia W, Zhu S, Guo X, Bian S, Kang J#. PAUPAR and PAX6 sequentially regulate human embryonic stem cell cortical differentiation. Nucleic Acids Res. 2021; 49(4):1935-50.

4. Chen W, Liu N, Shen S, Zhu W, Qiao J, Chang S, Dong J, Bai M, Ma L, Wang S, Jia W, Guo X, Li A, Xi J, Jiang C, Kang J#. Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring. Cell Rep. 2021; 37(5):109912.

5. Wang G, Yu J, Yang Y, Liu X, Guo X, Duan T#, Lu C#, Kang J#. Whole-transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction. Clin Transl Med. 2020; 9:9.

6. Qiao J, Zhao J, Chang S, Sun Q, Liu N, Dong J, Chen Y, Yang D, Ye D, Liu X, Yu Y, Chen W, Zhu S, Wang G, Jia W, Xi J#, Kang J#. MicroRNA-153 improves the neurogenesis of neural stem cells and enhances the cognitive ability of aged mice through the notch signaling pathway. Cell Death Differ. 2020; 27(2):808-25.

7. Yu Y, Jia W, Lyu Y, Su D, Bai M, Shen J, Qiao J, Han T, Liu W, Chen J, Chen W, Ye D, Guo X, Zhu S, Xi J, Zhu R, Wan X, Gao S, Zhu J, Kang J#. Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation. Cell Discov. 2019; 5:47.

8. Zhao J, Tang M, Cao J, Ye D, Guo X, Xi J, Zhou Y, Xia Y, Qiao J, Chai R, Yang X#, Kang J#. Structurally tunable reduced graphene oxide substrate maintains mouse embryonic stem cell pluripotency. Adv Sci (Weinh). 2019; 6(12):1802136.

9. Guo X, Xu Y, Wang Z, Wu Y, Chen J, Wang G, Lu C, Jia W, Xi J, Zhu S, Jiapaer Z, Wan X, Liu Z, Gao S, Kang J#. A Linc1405/Eomes complex promotes cardiac mesoderm specification and cardiogenesis. Cell Stem Cell. 2018; 22(6):893-908.

10. Zhu F, Zhu Q, Ye D, Zhang Q, Yang Y, Guo X, Liu Z, Jiapaer Z, Wan X, Wang G, Chen W, Zhu S, Jiang C, Shi W#, Kang J#. Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. Nucleic Acids Res. 2018; 46(12):6026-40.

11. Liu Z, Tang M, Zhao J, Chai R#, Kang J#. Looking into the future: toward advanced 3D biomaterials for stem-cell-based regenerative medicine. Adv Mater. 2018; 30(17):e1705388.

12.Yang D, Qiao J, Wang G, Lan Y, Li G, Guo X, Xi J, Ye D, Zhu S, Chen W, Jia W, Leng Y, Wan X, Kang J#. N6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential. Nucleic Acids Res. 2018; 46(8):3906-20.

13. Chen W, Liu N, Zhang H, Zhang H, Qiao J, Jia W, Zhu S, Mao Z, Kang J#. Sirt6 promotes DNA end joining in iPSCs derived from old mice. Cell Rep. 2017; 18(12):2880-92.

14. Wei T, Chen W, Wang X, Zhang M, Chen J, Zhu S, Chen L, Yang D, Wang G, Jia W, Yu Y, Duan T, Wu M, Liu H, Gao S, Kang J#. An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells. Nucleic Acids Res. 2015; 43(11):5409-22.

15. Wang G, Guo X, Hong W, Liu Q, Wei T, Lu C, Gao L, Ye D, Zhou Y, Chen J, Wang J, Wu M, Liu H, Kang J#. Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. PNAS 2013; 110(8):2858-63.

16. Guo X, Liu Q, Wang G, Zhu S, Gao L, Hong W, Chen Y, Wu M, Liu H, Jiang C, Kang J#. microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. Cell Res. 2013; 23:142-56.

17. Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Zhang X, Wang F, Yang R, Fan F, Pei G, Ma L. A nuclear function of beta-arrestin 1 in GPCR Signaling: regulation of histone acetylation and gene transcription. Cell 2005; 123:833-47.